In season two of the supernatural crime saga, core relationships deepen and become more complicated as everyone tries to put their lives back on track after one very insane day. Santánico and Richie (living outside of Houston) are now partners in crime, resembling a more modern version of Bonnie and Clyde; Seth and Kate are scraping by as small time criminals south of the border; and Freddie Gonzales has an almost obsessive focus on protecting his wife and young daughter in the suburbs. Carlos Madrigal and Scott Fuller emerge from the Titty Twister, changed men. They will all come together once again—this time facing off against an even bigger threat.
Based on the thrill-ride film, "From Dusk Till Dawn: The Series" is a supernatural crime saga centered around bank robber, Seth Gecko (Cotrona) and his violent, unpredictable brother, Richard "Richie" Gecko (Holtz), who are wanted by the FBI and Texas Rangers Earl McGraw (Johnson) and Freddie Gonzalez (Garcia) after a bank heist left several people dead. While on an escape route to Mexico, Seth and Richie encounter former minister Jacob Fuller and his family who they take hostage. Using the family RV to make a run for the Mexican border, chaos ensues when the group detours to a strip club that is unknowingly populated by vampires, and forces them to fight until dawn in order to get out alive. The series deepens the tone of the film, adds new characters and backstories and expands the Mesoamerican mythology behind the vampires.